Содержание
Количество страниц,
Год издания,
Переплет,
ISBN,
язык,
От автора
Количество страниц
196
Год издания
2010
Переплет
Мягкая обложка
ISBN
3838334507
язык
Английский
От автора
In addition to working together to drive expression of target genes, ?-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of ?-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ?-catenin-TCF interactions, in the T cell lineage. We found that ?-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ?-catenin-TCF interactions in normal thymic involution. We also discovered that ?-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ?-catenin. This study, thus, provides novel insights into the role of ?-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.
